Unable to connect to database - 15:15:58 Unable to connect to database - 15:15:58 SQL Statement is null or not a SELECT - 15:15:58 SQL Statement is null or not a DELETE - 15:15:58 Botany & Plant Biology 2007 - Abstract Search
Unable to connect to database - 15:15:58 Unable to connect to database - 15:15:58 SQL Statement is null or not a SELECT - 15:15:58

Abstract Detail


Cell-to-Cell and Long Distance Signaling

Pursel, Sydney [1], Chevalier, David [1], Walker, John [1].

The function of the Fork-head-associated domain in Arabidopsis thaliana.

Protein-Protein interactions are one of the elements of regulating signaling and cellular processes. These interactions are mediated between interaction domains and target motifs. The interaction domains bind specific target motifs from proteins so that protein binding is controlled and does not happen randomly. One of the target motifs is a phosphorylated protein. Several phosphobinding domains have been identified to bind phosphorylated tyrosine, threonine, and/or serine. One of theses domains is the fork-head-associated domain (FHA). The FHA domain is a phosphothreonine binding domain and has been found in proteins that are involved in DNA repair, cell cycle control and cell proliferation. In Arabidopsis thaliana, FHA domains have been identified in 16 genes including KAPP, ABA1, DDL and AtNBS1. My objective is to identify the function of other genes that encode a protein with a FHA domain. The function of these genes will be deduced from the phenotype of the homozygote mutants of these genes. I focus my research on one gene, AT5g07400. Besides the FHA domain both AT5g07400 and its animal orthologous gene have a tyrosyl-DNA phosphodiesterase domain, which is involved in DNA repair. I have isolated two independent homozygous mutants in AT5g07400 and am screening for phenotypes.


Log in to add this item to your schedule

1 - University of Missouri-Columbia, Division of Biological Sciences, 304 Life Science Center, Columbia, Missouri, 65211, USA

Keywords:
FHA domain
Arabidopsis thaliana
DNA repair.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P34008
Abstract ID:883


Copyright 2000-2007, Botanical Society of America. All rights