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Abstract Detail


Secondary Metabolism

Adams, Amber [1], Israr, Mohd [2], Clauson, Mark [2], Sahi, Shivendra [2].

Antifungal activity of oregano (Origanum vulgare ) oil against human pathogenic fungi.

The development of effective and less toxic antifungal agent is essential for the continued treatment of fungi causing diseases. Over the past two decades, several plants and their preparations have been assessed as combatants against pathogenic fungi. This study focuses on the antifungal activity of oil from Origanum vulgare. Oil from the oregano plant was extracted using steam distillation and solvent extraction. The oil was checked for different components via thin layer chromatography. Oil was furhter investigated for antifungal activity using disk diffusion susceptibility testing against Candida albicans. A 23.7 mm inhibition zone was noticed at a concentration of 500 μg oil extract after 48 hours of incubation. Though, in the control treatment the zone of inhibition was only 7.0 mm in diameter. Experiments are underway to determine the fungicidal activity of this oil against Cryptococcus neoformans, Saccharomyces cerevisiae and several other fungal strains. Further, the minimum inhibitory concentrations (MICc) against all tested species will also be examined. These results should be helpful to show the anti-fungal potential of oregano oil against pathogenic fungi.


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1 - Western Kentucky University, Biology, 1906 College Heights Blvd. #11080, Bowling Green, KY, 42101, USA
2 - Western Kentucky UNiversity, Biology

Keywords:
Pathogenic fungi
Fungal metabolites
Antifungal agents
Plant secondary metabolism.

Presentation Type: Plant Biology Abstract
Session: P
Location: Exhibit Hall (Northeast, Southwest & Southeast)/Hilton
Date: Sunday, July 8th, 2007
Time: 8:00 AM
Number: P20048
Abstract ID:2231


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